Challenge room locked at full health

Best Answer
This room is a boss challenge room, as denoted by the skull inside the swords, to enter it you need one heart or less of red hearts left, meaning that soul hearts do not count.
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How do you unlock Boss Challenge Rooms?
Boss Challenge Room Boss Challenge Rooms can only be entered if Isaac has one or fewer hearts of health. Picking up its contents will cause two waves of bosses to spawn.How do you open the sword door in binding of Isaac?
The doors are tied to your health. The door will only be open if you have full health. However, the temporary HP boosts (blue hearts) can serve as a equivalent of the missing red hearts. For example: If you're missing one red heart but have one blue heart the door will open.How do you get the sword room in binding of Isaac?
The challenge room can be recognized by the Gauntlet Door (a pair of crossed swords above the doorway). It can only be entered if the player is at full health (or the equivalent of full health, made up with Soul Hearts).48 hours of total isolation - Horizon - BBC
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Answer 2
The room appears to be a boss challenge room, indicated by the skull above the door. Additionally, the sword icon on your minimap has blood on it, which is also an indicator that the room is a boss challenge room.
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