Can I inbreed my family with another family?

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I know that inbreeding within a family can cause the characters to have bad traits so that the descendants can get mad or something like this.
But is it also possible to inbreed with another family? That is: If I am, for example, Byzantium and I always marry my heir off to Hungarian princesses, will this lead to the effects inbreeding has when done within the family?
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How closely related is considered inbreeding?
Inbreeding is technically defined as the mating of animals more closely related than the average relationship within the breed or population concerned. For practical purposes, if two mated individuals have no common ancestor within the last five or six generations, their progeny would be considered outbreds.What is the most inbred family?
Mark Laita first met the Whittaker family - who are widely regarded as America's most famous inbred family - after being granted access to their weird world. The family have little contact with anyone in the outside world and when Laita first attempted to photograph the family, neighbours threatened him.What happens if you inbreed too much?
Generally, inbreeding is more common in the southeast region of the U.S. and more rural states. Approximately 70% of inbred families live in desolate areas. Inbreeding is common, specifically, in the eastern part of Kentucky, and the region is plagued by the stereotype that every family is an inbred family.How much can you inbreed a family in The Sims 4? // Let’s break the family tree!
Sources: Stack Exchange - This article follows the attribution requirements of Stack Exchange and is licensed under CC BY-SA 3.0.
Images: Dazzle Jam, Dazzle Jam, Daria Shevtsova, RODNAE Productions